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Activation of hepatocyte growth factor by urokinase-type plasminogen activator is ionic strength-dependent

The hepatocyte growth factor (HGF) is a multifunctional cytokine that is produced as latent scHGF (single chain HGF). Various proteases reportedly cleave scHGF to generate the active two-chain form (HGF), including u-PA (urokinase-type plasminogen activator), t-PA (tissue-type plasminogen activator)...

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Detalhes bibliográficos
Main Authors: Mars, Wendy M., Jo, Minji, Gonias, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184584/
https://ncbi.nlm.nih.gov/pubmed/15869463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20042028
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