Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion

Genomic heterogeneity is characteristic of glioblastoma (GBM). In many GBMs, the EGF receptor gene (EGFR) is amplified and may be truncated to generate a constitutively active form of the receptor called EGFRvIII. EGFR gene amplification and EGFRvIII are associated with GBM progression, even when on...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Gilder, Andrew S., Jones, Karra A., Hu, Jingjing, Wang, Lei, Chen, Clark C., Carter, Bob S., Gonias, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463428/
https://ncbi.nlm.nih.gov/pubmed/25837250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637488
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