Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion

Genomic heterogeneity is characteristic of glioblastoma (GBM). In many GBMs, the EGF receptor gene (EGFR) is amplified and may be truncated to generate a constitutively active form of the receptor called EGFRvIII. EGFR gene amplification and EGFRvIII are associated with GBM progression, even when on...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gilder, Andrew S., Jones, Karra A., Hu, Jingjing, Wang, Lei, Chen, Clark C., Carter, Bob S., Gonias, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463428/
https://ncbi.nlm.nih.gov/pubmed/25837250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637488
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