Structural flexibility of the Gαs α-helical domain in the β(2)-adrenoceptor Gs complex

The active-state complex between an agonist-bound receptor and a guanine nucleotide-free G protein represents the fundamental signaling assembly for the majority of hormone and neurotransmitter signaling. We applied single-particle electron microscopy (EM) analysis to examine the architecture of ago...

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Detalhes bibliográficos
Main Authors: Westfield, Gerwin H., Rasmussen, Søren G. F., Su, Min, Dutta, Somnath, DeVree, Brian T., Chung, Ka Young, Calinski, Diane, Velez-Ruiz, Gisselle, Oleskie, Austin N., Pardon, Els, Chae, Pil Seok, Liu, Tong, Li, Sheng, Woods, Virgil L., Steyaert, Jan, Kobilka, Brian K., Sunahara, Roger K., Skiniotis, Georgios
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179071/
https://ncbi.nlm.nih.gov/pubmed/21914848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113645108
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