Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviors in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to t...

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Detalhes bibliográficos
Main Authors: Rasmussen, Søren G. F., Choi, Hee-Jung, Fung, Juan Jose, Pardon, Els, Casarosa, Paola, Chae, Pil Seok, DeVree, Brian T., Rosenbaum, Daniel M., Thian, Foon Sun, Kobilka, Tong Sun, Schnapp, Andreas, Konetzki, Ingo, Sunahara, Roger K., Gellman, Samuel H., Pautsch, Alexander, Steyaert, Jan, Weis, William I., Kobilka, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058308/
https://ncbi.nlm.nih.gov/pubmed/21228869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09648
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