Structure and Function of an Irreversible Agonist-β(2) Adrenoceptor complex

G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signaling in response to chemically diverse agonists. Despite recent progress in the structural biology of GPCRs1, the molecular basis for agonist binding and allost...

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Main Authors: Rosenbaum, Daniel M., Zhang, Cheng, Lyons, Joseph, Holl, Ralph, Aragao, David, Arlow, Daniel H., Rasmussen, Søren G. F., Choi, Hee-Jung, DeVree, Brian T., Sunahara, Roger K., Chae, Pil Seok, Gellman, Samuel H., Dror, Ron O., Shaw, David E., Weis, William I., Caffrey, Martin, Gmeiner, Peter, Kobilka, Brian K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074335/
https://ncbi.nlm.nih.gov/pubmed/21228876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09665
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