Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

Igs offer a versatile template for combinatorial and rational design approaches to the de novo creation of catalytically active proteins. We have used a covalent capture selection strategy to identify biocatalysts from within a human semisynthetic antibody variable fragment library that uses a nucle...

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Autors principals: Smirnov, Ivan, Carletti, Eugénie, Kurkova, Inna, Nachon, Florian, Nicolet, Yvain, Mitkevich, Vladimir A., Débat, Hélène, Avalle, Bérangère, Belogurov, Alexey A., Kuznetsov, Nikita, Reshetnyak, Andrey, Masson, Patrick, Tonevitsky, Alexander G., Ponomarenko, Natalia, Makarov, Alexander A., Friboulet, Alain, Tramontano, Alfonso, Gabibov, Alexander
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179052/
https://ncbi.nlm.nih.gov/pubmed/21896761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108460108
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