Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents

Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). The inhibited cholinesterases can be reactivated using oximes, but a spontaneous time-dependent process called aging alters the adduct, lead...

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Detalhes bibliográficos
Principais autores: Wandhammer, Marielle, Carletti, Eugénie, Van der Schans, Marcel, Gillon, Emilie, Nicolet, Yvain, Masson, Patrick, Goeldner, Maurice, Noort, Daan, Nachon, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089521/
https://ncbi.nlm.nih.gov/pubmed/21454498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209569
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