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Enzyme mimicry by the antiidiotypic antibody approach

The concept of “internal image” of antiidiotypic antibodies has provided the basis for eliciting catalytic antibodies. A monoclonal IgM 9A8 that was obtained as an antiidiotype to AE-2 mAb, a known inhibitor of acetylcholinesterase, displayed esterolytic activity. Study of recombinant Fab fragments...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kolesnikov, Alexander V., Kozyr, Arina V., Alexandrova, Elena S., Koralewski, Frédéric, Demin, Alexander V., Titov, Mikhail I., Avalle, Bérangère, Tramontano, Alfonso, Paul, Sudhir, Thomas, Daniel, Gabibov, Alexander G., Friboulet, Alain
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17609/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.200360497
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