Enzyme mimicry by the antiidiotypic antibody approach

The concept of “internal image” of antiidiotypic antibodies has provided the basis for eliciting catalytic antibodies. A monoclonal IgM 9A8 that was obtained as an antiidiotype to AE-2 mAb, a known inhibitor of acetylcholinesterase, displayed esterolytic activity. Study of recombinant Fab fragments...

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Detalhes bibliográficos
Main Authors: Kolesnikov, Alexander V., Kozyr, Arina V., Alexandrova, Elena S., Koralewski, Frédéric, Demin, Alexander V., Titov, Mikhail I., Avalle, Bérangère, Tramontano, Alfonso, Paul, Sudhir, Thomas, Daniel, Gabibov, Alexander G., Friboulet, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17609/
https://ncbi.nlm.nih.gov/pubmed/11095704
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