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Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence()

We generated from a single blood sample five independent human monoclonal antibodies that recognized the Sa antigenic site on the head of influenza HA and exhibited inhibitory activity against a broad panel of H1N1 strains. All five Abs used the V(H)3-7 and J(H)6 gene segments, but at least four ind...

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Main Authors: Krause, Jens C., Tsibane, Tshidi, Tumpey, Terrence M., Huffman, Chelsey J., Briney, Bryan S., Smith, Scott A., Basler, Christopher F., Crowe, James E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178754/
https://ncbi.nlm.nih.gov/pubmed/21880983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101823
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