A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin

The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum o...

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Hlavní autoři: Krause, Jens C., Tsibane, Tshidi, Tumpey, Terrence M., Huffman, Chelsey J., Basler, Christopher F., Crowe, James E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187471/
https://ncbi.nlm.nih.gov/pubmed/21849447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00700-11
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