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Genome wide expression profiling and mutagenesis studies reveal that LPS responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions
Lipid A (a hexaacylated 1,4’ bis-phosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. Here we define the role of TLR4...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178671/ https://ncbi.nlm.nih.gov/pubmed/21865549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101397 |
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