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MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation
Lipopolysaccharide (LPS) activates innate immune responses through TLR4·MD-2. LPS binds to the MD-2 hydrophobic pocket and bridges the dimerization of two TLR4·MD-2 complexes to activate intracellular signaling. However, exactly how lipid A, the endotoxic moiety of LPS, activates myeloid lineage cel...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838292/ https://ncbi.nlm.nih.gov/pubmed/20018893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075127 |
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