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Mass Spectrometry-based Protein Footprinting Characterizes the Structures of Oligomeric Apolipoprotein E2, E3, and E4
The three common isoforms of apolipoprotein E (ApoE) differ at two sites in their 299 amino-acid sequence; these differences modulate the structure of ApoE to affect profoundly the isoform associations with disease. The ε4 allele in particular is strongly associated with Alzheimer’s disease. The stu...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177987/ https://ncbi.nlm.nih.gov/pubmed/21848287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200911c |
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