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Mass Spectrometry-based Protein Footprinting Characterizes the Structures of Oligomeric Apolipoprotein E2, E3, and E4

The three common isoforms of apolipoprotein E (ApoE) differ at two sites in their 299 amino-acid sequence; these differences modulate the structure of ApoE to affect profoundly the isoform associations with disease. The ε4 allele in particular is strongly associated with Alzheimer’s disease. The stu...

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Detalhes bibliográficos
Main Authors: Gau, Brian, Garai, Kanchan, Frieden, Carl, Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177987/
https://ncbi.nlm.nih.gov/pubmed/21848287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200911c
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