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Hydrogen/Deuterium Exchange and Electron-Transfer Dissociation Mass Spectrometry Determine the Interface and Dynamics of Apolipoprotein E Oligomerization

Apolipoprotein E, a 34 kDa protein, plays a key role in triglyceride and cholesterol metabolism. Of the three common isoforms (ApoE2, 3 and 4), only ApoE4 is a risk factor for Alzheimer’s Disease. All three isoforms of wild-type ApoE self-associate to form oligomers, a process that may have function...

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Autors principals: Huang, Richard Y-C., Garai, Kanchan, Frieden, Carl, Gross, Michael L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202646/
https://ncbi.nlm.nih.gov/pubmed/21899263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2010027
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