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Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry

Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic digestion. This limitation can be selectively overcome through the use of electron-transfer dissociation to fragment peptides in a manner th...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Masson, Glenn R., Maslen, Sarah L., Williams, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544108/
https://ncbi.nlm.nih.gov/pubmed/28381646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170127
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