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Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors
A small set of boronic acids acting as low nanomolar inhibitors of AmpC β-lactamase were designed and synthesized in the effort to improve affinity, pharmacokinetic properties, and to provide a valid lead compound. X-ray crystallography revealed the binary complex of the best inhibitor bound to the...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177945/ https://ncbi.nlm.nih.gov/pubmed/20452208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.007 |
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