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Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

[Image: see text] Production of β-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight β-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent need for novel BL inhibitors. Boron...

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Detalhes bibliográficos
Main Authors: Tondi, Donatella, Venturelli, Alberto, Bonnet, Richard, Pozzi, Cecilia, Shoichet, Brian K., Costi, Maria Paola
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079326/
https://ncbi.nlm.nih.gov/pubmed/24882105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5006572
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