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The Deacylation Mechanism of AmpC β-Lactamase at Ultrahigh Resolution
β-Lactamases confer bacterial resistance to β-lactam antibiotics, such as penicillins. The characteristic class C β-lactamase AmpC catalyzes the reaction with several key residues including Ser64, Tyr150, and Lys67. Here, we describe a 1.07 Å X-ray crystallographic structure of AmpC β-lactamase in c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544378/ https://ncbi.nlm.nih.gov/pubmed/16506777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja056806m |
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