Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Mutations in leucine-rich repeat kinase 2 (LRRK2) have been identified as a genetic cause of familial Parkinson's disease (PD) and have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease-causi...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Zhaohui, Hamamichi, Shusei, Dae Lee, Byoung, Yang, Dejun, Ray, Arpita, Caldwell, Guy A., Caldwell, Kim A., Dawson, Ted M., Smith, Wanli W., Dawson, Valina L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177653/
https://ncbi.nlm.nih.gov/pubmed/21768216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr312
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