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Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection.

Efficient solid-phase synthesis of a series of oligoribonucleotides of up to 20 residues is described that utilises the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection and 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection of ribonucleotide monomers and a phosphoramidite coup...

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Detalles Bibliográficos
Main Authors: Lehmann, C, Xu, Y Z, Christodoulou, C, Tan, Z K, Gait, M J
Formato: Artigo
Idioma:Inglês
Publicado: 1989
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC317630/
https://ncbi.nlm.nih.gov/pubmed/2717397
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