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Studies on the t-butyldimethylsilyl group as 2'-O-protection in oligoribonucleotide synthesis via the H-phosphonate approach.

Two model compounds, 1 and 2, have been studied to test the stability of the t-butyldimethylsilyl (t-BDMSi) group towards conditions used during chemical synthesis of RNA fragments by the H-phosphonate approach. When 1 was treated with anhydrous acid for 16 h both the H-phosphonate diester and the t...

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Détails bibliographiques
Auteurs principaux: Stawinski, J, Strömberg, R, Thelin, M, Westman, E
Format: Artigo
Langue:Inglês
Publié: 1988
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC338706/
https://ncbi.nlm.nih.gov/pubmed/3174451
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