Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach

Abstract Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising type of antisense oligonucleotides, but their challenging synthesis makes them difficult to access. This research presents an efficient synthetic approach for PMOs using the H-phosphonate approach. The use of phosphonium-...

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Autors principals:	Taiki Tsurusaki, Kazuki Sato, Hiroki Imai, Kunihiro Hirai, Daisuke Takahashi, Takeshi Wada
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2023-08-01
Col·lecció:	Scientific Reports
Accés en línia:	https://doi.org/10.1038/s41598-023-38698-2
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