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The H-phosphonate approach to the solution phase synthesis of linear and cyclic oligoribonucleotides.

The solution phase synthesis of the tetraribonucleoside triphosphate r(ApCpGpU) 18 and the corresponding cyclic tetraribonucleotide 19 is described. The synthetic methodology is based on 5'- O -(DMTr)-2'- O -(Fpmp)-ribonucleoside-3'- H -phosphonate building blocks 10. Coupling, which...

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Bibliografische gegevens
Hoofdauteurs: Reese, C B, Song, Q
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC148274/
https://ncbi.nlm.nih.gov/pubmed/9927727
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