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The H-phosphonate approach to the solution phase synthesis of linear and cyclic oligoribonucleotides.

The solution phase synthesis of the tetraribonucleoside triphosphate r(ApCpGpU) 18 and the corresponding cyclic tetraribonucleotide 19 is described. The synthetic methodology is based on 5'- O -(DMTr)-2'- O -(Fpmp)-ribonucleoside-3'- H -phosphonate building blocks 10. Coupling, which...

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Detalles Bibliográficos
Autores principales: Reese, C B, Song, Q
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC148274/
https://ncbi.nlm.nih.gov/pubmed/9927727
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