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The H-phosphonate approach to the solution phase synthesis of linear and cyclic oligoribonucleotides.

The solution phase synthesis of the tetraribonucleoside triphosphate r(ApCpGpU) 18 and the corresponding cyclic tetraribonucleotide 19 is described. The synthetic methodology is based on 5'- O -(DMTr)-2'- O -(Fpmp)-ribonucleoside-3'- H -phosphonate building blocks 10. Coupling, which...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Reese, C B, Song, Q
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC148274/
https://ncbi.nlm.nih.gov/pubmed/9927727
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