Role of TGFβ/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix Proteins

PURPOSE. The bone morphogenic protein (BMP) antagonist gremlin is elevated in glaucomatous trabecular meshwork (TM) cells and tissues and elevates intraocular pressure (IOP). Gremlin also blocks BMP4 inhibition of transforming growth factor (TGF)-β2 induction of TM extracellular matrix (ECM) protein...

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Bibliographic Details
Main Authors: Sethi, Anirudh, Jain, Ankur, Zode, Gulab S., Wordinger, Robert J., Clark, Abbot F.
Format: Artigo
Language:Inglês
Published: Association for Research in Vision and Ophthalmology, Inc. 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176052/
https://ncbi.nlm.nih.gov/pubmed/21642622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-7587
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