Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via...

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Bibliographic Details
Main Authors: Zhang, Qian, Wang, HongYi, Kantekure, Kanchan, Paterson, Jennifer C., Liu, Xiaobin, Schaffer, Andras, Paulos, Chrystal, Milone, Michael C., Odum, Niels, Turner, Suzanne, Marafioti, Teresa, Wasik, Mariusz A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175783/
https://ncbi.nlm.nih.gov/pubmed/21765024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332916
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