Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

Anaplastic lymphoma kinase (ALK) physiologically expressed only by nervous system cells displays remarkable capacity to transform CD4+ T lymphocytes and other types of non-neural cells. Here we report that activity of nucleophosphmin (NPM)/ALK chimeric protein, the dominant form of ALK expressed in...

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Bibliografiske detaljer
Main Authors: Marzec, Michal, Halasa, Krzysztof, Liu, Xiaobin, Wang, Hong Y., Cheng, Mangeng, Baldwin, Donald, Tobias, John W., Schuster, Stephen J., Woetmann, Anders, Zhang, Qian, Turner, Suzanne D., Odum, Niels, Wasik, Mariusz A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889215/
https://ncbi.nlm.nih.gov/pubmed/24218456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300744
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