Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Zhang, Qian, Wang, HongYi, Kantekure, Kanchan, Paterson, Jennifer C., Liu, Xiaobin, Schaffer, Andras, Paulos, Chrystal, Milone, Michael C., Odum, Niels, Turner, Suzanne, Marafioti, Teresa, Wasik, Mariusz A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175783/
https://ncbi.nlm.nih.gov/pubmed/21765024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332916
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki