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Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS
Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society of Hematology
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175783/ https://ncbi.nlm.nih.gov/pubmed/21765024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332916 |
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