The Potent Oncogene NPM-ALK Mediates Malignant Transformation of Normal Human CD4(+) T Lymphocytes

With this study we have demonstrated that in vitro transduction of normal human CD4(+) T lymphocytes with NPM-ALK results in their malignant transformation. The transformed cells become immortalized and display morphology and immunophenotype characteristic of patient-derived anaplastic large-cell ly...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Zhang, Qian, Wei, Fang, Wang, Hong Yi, Liu, Xiaobin, Roy, Darshan, Xiong, Qun-Bin, Jiang, Shuguang, Medvec, Andrew, Danet-Desnoyers, Gwenn, Watt, Christopher, Tomczak, Ewa, Kalos, Michael, Riley, James L., Wasik, Mariusz A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745542/
https://ncbi.nlm.nih.gov/pubmed/24404580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.030
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