Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase

We report an efficient synthetic route to chiral pyrrolidine inhibitors of neuronal nitric oxide synthase (nNOS) and crystal structures of the inhibitors bound to nNOS and to endothelial NOS. The new route enables versatile structure activity relationship studies on the pyrrolidine-based scaffold, w...

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Detalhes bibliográficos
Main Authors: Xue, Fengtian, Kraus, James M., Labby, Kristin Jansen, Ji, Haitao, Mataka, Jan, Xia, Guoyao, Li, Huiying, Delker, Silvia L., Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174355/
https://ncbi.nlm.nih.gov/pubmed/21809851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200411j
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