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Loss of Granuphilin and Loss of Syntaxin-1A Cause Differential Effects on Insulin Granule Docking and Fusion

The Rab27 effector granuphilin/Slp4 is essential for the stable attachment (docking) of secretory granules to the plasma membrane, and it also inhibits subsequent fusion. Granuphilin is thought to mediate these processes through interactions with Rab27 on the granule membrane and with syntaxin-1a on...

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書誌詳細
主要な著者: Wang, Hao, Ishizaki, Ray, Kobayashi, Eri, Fujiwara, Tomonori, Akagawa, Kimio, Izumi, Tetsuro
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173164/
https://ncbi.nlm.nih.gov/pubmed/21768089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268631
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