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The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane
Granuphilin, an effector of the small GTPase Rab27a, mediates the stable attachment (docking) of insulin granules to the plasma membrane and inhibits subsequent fusion of docked granules, possibly through interaction with a fusion-inhibitory Munc18-1/syntaxin complex. However, phenotypes of insulin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564536/ https://ncbi.nlm.nih.gov/pubmed/23223571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-04-0265 |
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