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Loss of Granuphilin and Loss of Syntaxin-1A Cause Differential Effects on Insulin Granule Docking and Fusion
The Rab27 effector granuphilin/Slp4 is essential for the stable attachment (docking) of secretory granules to the plasma membrane, and it also inhibits subsequent fusion. Granuphilin is thought to mediate these processes through interactions with Rab27 on the granule membrane and with syntaxin-1a on...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173164/ https://ncbi.nlm.nih.gov/pubmed/21768089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268631 |
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