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Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion
DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone carbonyl of Tyr-271; alanine substitution of Tyr-271, but not Phe-272, resulted in a >10-fold loss in discrimination. The Y271A mutant also inser...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173102/ https://ncbi.nlm.nih.gov/pubmed/21733843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253401 |
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