Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion

DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone carbonyl of Tyr-271; alanine substitution of Tyr-271, but not Phe-272, resulted in a >10-fold loss in discrimination. The Y271A mutant also inser...

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Autores principales: Cavanaugh, Nisha A., Beard, William A., Batra, Vinod K., Perera, Lalith, Pedersen, Lee G., Wilson, Samuel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173102/
https://ncbi.nlm.nih.gov/pubmed/21733843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253401
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