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Understanding the errors of SHAPE-directed RNA structure modeling

Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2´-hydroxyl acylation by primer extension (SHAPE) can give near-zero error rates (0–2%) in...

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Dettagli Bibliografici
Autori principali: Kladwang, Wipapat, VanLang, Christopher C., Cordero, Pablo, Das, Rhiju
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172344/
https://ncbi.nlm.nih.gov/pubmed/21842868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200524n
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