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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Oncogenic Ras transforms immortal rodent cells to a tumorigenic state, in part, by constitutively transmitting mitogenic signals through the mitogen-activated protein kinase (MAPK) cascade. In primary cells, Ras is initially mitogenic but eventually induces premature senescence involving the p53 and...

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Udgivet i:Genes Dev
Principais autores: Lin, Athena W., Barradas, Marta, Stone, James C., van Aelst, Linda, Serrano, Manuel, Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317198/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9765203/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.19.3008
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