Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

RAG1 and RAG2 initiate V(D)J recombination, the process of rearranging the antigen-binding domain of immunoglobulins and T-cell receptors, by introducing site-specific double-strand breaks (DSB) in chromosomal DNA during lymphocyte development. These breaks are generated in two steps, nicking of one...

Descrición completa

Detalles Bibliográficos

Publicado en:	Genes Dev
Principais autores:	Landree, Mark A., Wibbenmeyer, Jamie A., Roth, David B.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 1999
Assuntos:	Research Paper
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10601032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.23.3059
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!