Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

RAG1 and RAG2 initiate V(D)J recombination, the process of rearranging the antigen-binding domain of immunoglobulins and T-cell receptors, by introducing site-specific double-strand breaks (DSB) in chromosomal DNA during lymphocyte development. These breaks are generated in two steps, nicking of one...

Descripció completa

Dades bibliogràfiques

Publicat a:	Genes Dev
Autors principals:	Landree, Mark A., Wibbenmeyer, Jamie A., Roth, David B.
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 1999
Matèries:	Research Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10601032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.23.3059
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!