Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

RAG1 and RAG2 initiate V(D)J recombination, the process of rearranging the antigen-binding domain of immunoglobulins and T-cell receptors, by introducing site-specific double-strand breaks (DSB) in chromosomal DNA during lymphocyte development. These breaks are generated in two steps, nicking of one...

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Pubblicato in:	Genes Dev
Autori principali:	Landree, Mark A., Wibbenmeyer, Jamie A., Roth, David B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10601032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.23.3059
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