Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines

Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of non-histone proteins including tumor suppressor p53. We previously reported the discovery of UNC...

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Autors principals: Liu, Feng, Barsyte-Lovejoy, Dalia, Allali-Hassani, Abdellah, He, Yunlong, Herold, J. Martin, Chen, Xin, Yates, Christopher M., Frye, Stephen V., Brown, Peter J., Huang, Jing, Vedadi, Masoud, Arrowsmith, Cheryl H., Jin, Jian
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171737/
https://ncbi.nlm.nih.gov/pubmed/21780790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200903z
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