Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001) analogs: Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model

In a continuing study of our clinical candidate 5 (VN/124-1 or TOK-001) and analogs as potential agents for prostate cancer therapy, putative metabolites (10, 15 and 18) of compound 5 were rationally designed and synthesized. However, none of these agents were as efficacious as 5 in several in vitro...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Bruno, Robert D., Vasaitis, Tadas S., Gediya, Lalji K., Purushottamachar, Puranik, Godbole, Abhijit M., Ates-Alagoz, Zeynep, Brodie, Angela M. H., Njar, Vincent C. O.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2011
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171567/
https://ncbi.nlm.nih.gov/pubmed/21729712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2011.06.002
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