Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle. Biochemical and genetic studies have demonstrated overlapping as well as distinct functions for the three proteins in cell cycle control and mouse development. Howeve...

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Autors principals: Sage, Julien, Mulligan, George J., Attardi, Laura D., Miller, Abigail, Chen, SiQi, Williams, Bart, Theodorou, Elias, Jacks, Tyler
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2000
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC317090/
https://ncbi.nlm.nih.gov/pubmed/11114892
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