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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle. Biochemical and genetic studies have demonstrated overlapping as well as distinct functions for the three proteins in cell cycle control and mouse development. Howeve...

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Hlavní autoři: Sage, Julien, Mulligan, George J., Attardi, Laura D., Miller, Abigail, Chen, SiQi, Williams, Bart, Theodorou, Elias, Jacks, Tyler
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC317090/
https://ncbi.nlm.nih.gov/pubmed/11114892
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