SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

Mutant p53 (mutp53) cancers are surprisingly dependent on their hyperstable mutp53 protein for survival, identifying mutp53 as a potentially significant clinical target. However, exploration of effective small molecule therapies targeting mutp53 has barely begun. Mutp53 hyperstabilization, a hallmar...

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Bibliographic Details
Main Authors: Li, D, Marchenko, N D, Moll, U M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170683/
https://ncbi.nlm.nih.gov/pubmed/21637290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.71
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