ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein

Hsp90 is a ubiquitous, ATP-dependent chaperone, essential for eukaryotes. It possesses a broad spectrum of substrates, among which is the p53 transcription factor, encoded by a tumor-suppressor gene. Here, we elucidate the role of the adenine nucleotide in the Hsp90 chaperone cycle, by taking advant...

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Bibliografiske detaljer
Main Authors: Walerych, Dawid, Gutkowska, Malgorzata, Klejman, Marcin P., Wawrzynow, Bartosz, Tracz, Zuzanna, Wiech, Milena, Zylicz, Maciej, Zylicz, Alicja
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952203/
https://ncbi.nlm.nih.gov/pubmed/20688913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112110
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