The Physical Association of Multiple Molecular Chaperone Proteins with Mutant p53 Is Altered by Geldanamycin, an hsp90-Binding Agent

Wild-type p53 is a short-lived protein which turns over very rapidly via selective proteolysis in the ubiquitin-proteasome pathway. Most p53 mutations, however, encode for protein products which display markedly increased intracellular levels and are associated with positive tumor-promoting activity...

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מידע ביבליוגרפי
Main Authors: Whitesell, Luke, Sutphin, Patrick D., Pulcini, Elizabeth J., Martinez, Jesse D., Cook, Paul H.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 1998
נושאים:
Cell Growth and Development
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC108866/
https://ncbi.nlm.nih.gov/pubmed/9488468
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