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Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis. However, the molecular mechanism facilitating MIF stabilization in tumors...

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Autors principals: Schulz, Ramona, Marchenko, Natalia D., Holembowski, Lena, Fingerle-Rowson, Günter, Pesic, Marina, Zender, Lars, Dobbelstein, Matthias, Moll, Ute M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280870/
https://ncbi.nlm.nih.gov/pubmed/22271573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111117
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