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Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis. However, the molecular mechanism facilitating MIF stabilization in tumors...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Schulz, Ramona, Marchenko, Natalia D., Holembowski, Lena, Fingerle-Rowson, Günter, Pesic, Marina, Zender, Lars, Dobbelstein, Matthias, Moll, Ute M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Rockefeller University Press 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280870/
https://ncbi.nlm.nih.gov/pubmed/22271573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111117
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