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Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis. However, the molecular mechanism facilitating MIF stabilization in tumors...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schulz, Ramona, Marchenko, Natalia D., Holembowski, Lena, Fingerle-Rowson, Günter, Pesic, Marina, Zender, Lars, Dobbelstein, Matthias, Moll, Ute M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280870/
https://ncbi.nlm.nih.gov/pubmed/22271573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111117
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